Hydrophilic Interaction Liquid Chromatography for LC-MS
نویسندگان
چکیده
منابع مشابه
Hydrophilic interaction chromatography (HILIC) for LC-MS/MS analysis of monoamine neurotransmitters.
BACKGROUND Hydrophilic interaction chromatography (HILIC) is becoming an increasingly popular alternative to traditional reversed-phase chromatography for the analysis of polar compounds. The ability to retain the most polar compounds in HILIC makes it attractive for the analysis of certain large groups of compounds, such as monoamines, which are inherently very polar. RESULTS This paper deta...
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A target value for iminoctadine triacetate residues in tap water was set at 6 microg/l in Japan. We have developed a highly selective and sensitive analytical method for iminoctadine triacetate by solid phase extraction LC/ESI/MS using hydrophilic interaction chromatography. The recovery rates at concentration of 0.06, 0.6, and 6 microg/l in distilled water, tap water, and raw water were 77.1 -...
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In proteomics, nanoflow multidimensional chromatography is now the gold standard for the separation of complex mixtures of peptides as generated by in-solution digestion of whole-cell lysates. Ideally, the different stationary phases used in multidimensional chromatography should provide orthogonal separation characteristics. For this reason, the combination of strong cation exchange chromatogr...
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■ ■ 2.5 μm particle size provides the flexibility to operate on a variety of systems IN T RO DU C T IO N Hydrophilic-interaction chromatography (HILIC) is increasingly becoming a method of choice for the analysis of polar compounds [1-5]. One set of polar analytes that poses particular challenges are the monoamine neurotransmitters, dopamine (DA), serotonin (5-HT), epinephrine (EP), and norepin...
متن کاملAn arginine-functionalized stationary phase for hydrophilic interaction liquid chromatography.
An arginine-functionalized stationary phase for hydrophilic interaction liquid chromatography (HILIC) has been prepared for the first time by clicking arginine onto silica gel. It offers an efficient separation of organic acids, nucleotides and sugars. More interestingly, it exhibited excellent selectivity and enrichment toward acidic glycopeptides, even at a ratio of 1 : 150 to non-glycopeptides.
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ژورنال
عنوان ژورنال: Mass Spectrometry & Purification Techniques
سال: 2018
ISSN: 2469-9861
DOI: 10.4172/2469-9861.1000123